MakeUsWell

All of Us

The Clue We Didn't Know to Look For

By Michael J. Critelli | MakeUsWell Newsletter, 


Recently, I spoke with a nutritionist about our food intelligence product. We began talking about food allergies and sensitivities, an issue that affects a great many people.

One example was deceptively simple: someone experiences digestive distress after eating a sandwich made with whole-wheat bread.

The natural conclusion might be: Something about wheat doesn't agree with me. That could lead to questions about celiac disease, wheat allergy or non-celiac gluten/wheat sensitivity.

But there is another possibility many people would never think to investigate: fructans.

The Fat We Don’t Measure

By Michael J. Critelli | MakeUsWell Newsletter, 


One of our beta users for our food intelligence product asked a question about visceral fat. To be honest, I did not understand the importance of this biometric health indicator, which, in itself, is a symptom of a problem with our primary care system. 

For decades, the way most of us have thought about body fat has been remarkably simple: weigh yourself, calculate your BMI, and try not to gain too much weight.

But those numbers can miss something important: Where fat is stored may matter almost as much as how much of it we carry.

Visceral fat is the fat that accumulates deep inside the abdomen around organs such as the liver and intestines. It is different from the subcutaneous fat we can pinch under the skin. Visceral fat is metabolically active and is strongly associated with insulin resistance, type 2 diabetes, high blood pressure, fatty liver disease and cardiovascular disease.

That means two people of the same height and weight, and therefore the same BMI, can have very different metabolic risk.

If You Can’t Cook More, Assemble Better.

By Michael J. Critelli | MakeUsWell Newsletter, 


One of the most common explanations people give for eating poorly is simple: “I don’t have time to eat healthy.”

For many people, that statement feels unquestionably true. Cooking has come to mean planning meals, shopping for ingredients, chopping vegetables, preparing meat or fish, cooking everything, and then cleaning up afterward. 

After a long workday, ordering a pizza, picking up fast food, or microwaving a packaged meal can seem like the only realistic option.

But there is a flaw in the premise: Eating healthy does not require cooking from scratch. It also does not mean investing time and money in eating at a regular restaurant at which a meal can consume an hour, or even at a restaurant popularly called a “fast casual” dining experience. It also does not relegate us to fast-food restaurants or take out restaurants serving highly processed foods with low nutritional value.

When a Drink Becomes a Delivery System

By Michael J. Critelli | MakeUsWell Newsletter, 


One of the most consequential insights in the history of consumer marketing came from Roberto Goizueta, Coca-Cola's legendary CEO.

Instead of thinking about Coca-Cola's market as soft drinks, Goizueta encouraged the company to think about all the fluids people consumed. Coca-Cola's 1996 annual report calculated its market opportunity using an assumed daily fluid intake of 64 ounces per person. Suddenly, Coke wasn't competing primarily with Pepsi. It was competing with water, coffee, tea, juice and virtually everything else people drank.

That seemingly simple reframing helped change the beverage business. Over time, Coca-Cola and its competitors expanded far beyond traditional carbonated soft drinks into sports drinks, energy drinks, bottled water, coffee, tea, flavored and sparkling waters, mixers and other beverages. Dasani, a still water, for example, was launched in North America in 1999.

But something more significant has happened.

The Injectable Self: When Appearance, Longevity and Distrust Collide.

By Michael J. Critelli | MakeUsWell Newsletter, 


Every July 4, our younger son and daughter-in-law invite about 40-50 friends, ages between 30 and 40 for a party at our Connecticut home. We get a quick tutorial on trends in this generation, although, fortunately relative to this one, not with our family members and their invitees.

One trend is the significant increase in online acquisition and use of self-injectible peptides. The word “peptide” has become a marketing category for substances promoted to reduce weight, build muscle, accelerate recovery, improve skin, increase energy and slow aging. Some are approved prescription drugs.

Peptides are short chains of amino acids, the same basic building blocks that make up proteins. Many occur naturally in the body and act as chemical messengers, influencing appetite, growth, metabolism, inflammation and tissue repair. Some peptide-based drugs are among medicine’s most important treatments. Insulin is a peptide hormone, and the widely used GLP-1 drugs for diabetes and obesity act through peptide-related pathways.